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KMID : 0377619970620090764
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Korean Jungang Medical Journal
1997 Volume.62 No. 9 p.764 ~ p.764
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Management of Pregnancy Complicated with SLE
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Yoshinori, Kuwabara
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Abstract
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Systemic lupus erythematosus(SLE) is a disease that primarily affects women of child-bearing age. Whether SLE is affected by pregnancy and whether the likelihood for a successful outcome is reduced in patients with SLE are issues of concern. The question whether pregnancy adversely affects SLE and causes a heightened incidence of clinical flares and/or increased severity of flares remains undetermined. Pregnancy in women with SLE are recognized to result in excessive fetal morbidity and mortality. Maternal autoantibody status may explain some of these problems.
Anti phospholipids antibodies which were originally detected in patients with SLE, have been associated with recurrent fetal losses.
Neonatal lupus syndrome(NSL), especially congenital complete heart block, is another issue of concern in pregnancies with SLE. NLS is a result of the transfer of auto antibodies produced by the mother, across the placenta, to the fetus and it is recognized as a model of passively acquired autoimmune mediated tissue damage.
Since 1983, we have been managing more than 100 pregnancies with SLE in Juntendo University Hospital. In view of our experiences, I will present some topics in the management of pregnancy with SLE.
The content of my presentation is as follows:
1. Pregnancy outcomes in women with SLE
2. Association of maternal auto antibodies with fetal outcome
3. Treatment of mother with anti phospholipids antibodies
4. Neonatal lupus syndrome
5. New management of high risk lupus pregnancy
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KEYWORD
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